Radiopharmaceuticals for diagnosis and treatment
We report on our efforts in PET basic radiochemistry, radiopharmaceutical synthesis, and preclinical radiopharmaceutical evaluation. These efforts are focused on three fronts. First predictive abilities in nucleophilic aromatic substitution with [[sup 18]F]fluorination of substituted aromatic rings. Although radiochemical yields can be predicted within a very similar group of compounds with similar leaving groups and substituent patterns, generalization to all nucleophilic substitutions with [[sup 18]F] fluoride is not warranted. Kinetic studies indicate significantly different rates of reactions, depending on ring substituents. Second, preclinical evaluation of new radiopharmaceuticals. We have synthesized and begun the preclinical evaluation of [[sup 11]C]tetrabenazine, a new radioligand based on the vesicular monoamine transport system. Third, our work, on [[sup 18]F]fluorination/decarbonylation reactions, structure-activity relationships in dopamine uptake inhibitors and effects of chronic drugs on radioligand binding is described.
- Research Organization:
- Michigan Univ., Ann Arbor, MI (United States). Div. of Nuclear Medicine
- Sponsoring Organization:
- DOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-88ER60639
- OSTI ID:
- 6895233
- Report Number(s):
- DOE/ER/60639-5; ON: DE93004637
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL PREPARATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOCUMENT TYPES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
IN VIVO
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NANOSEC LIVING RADIOISOTOPES
NERVOUS SYSTEM
NITRILES
NITRO COMPOUNDS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
PROGRESS REPORT
PSYCHOTROPIC DRUGS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RODENTS
SYNTHESIS
TOMOGRAPHY
TRANQUILIZERS
VERTEBRATES