/sup 123m/Te-labeled biochemicals and method of preparation

Patent · Tue Jul 29 04:00:00 EDT 1980

OSTI ID:6888387

Knapp, F

A process for preparing a /sup 123m/Te-labeled organic compound of the formula R-/sup 123m/Te-CH/sub 2/-R', R being alkyl, substituted alkyl, aryl or substituted aryl and R' being a steroidal side chain, alkyl amino acid or amino acid group, said process comprising the steps of: (A) reaching a /sup 123m/Te-symmetric diorgano ditelluride, R/sub 2//sup 123m/Te/sub 2/, R being alkyl, substituted alkyl, aryl or substituted aryl, with a hydride reducing agent and a source of alkali metal ions to form an alkali metal organo telluride M-/sup 123m/Te-R; (B) reacting said alkali metal organo telluride with a primary halogenated organic compound R/sub a/'-X, R/sub a/' being a 17 alkyl steroid group having 1-4 carbon atoms in said alkyl group, an alkyl amino acid group, or a group hydrolyzable to an alkyl amino acid group.

• Assignee: Department of Energy
• Patent Number(s): US 4215045
• OSTI ID: 6888387
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400300 -- Organic Chemistry-- (-1987)
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ALKALI METALS
ALKALINE EARTH METAL COMPOUNDS
AMINO ACIDS
BIOCHEMISTRY
BIOLOGY
BOROHYDRIDES
BORON COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL PREPARATION
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GRIGNARD REAGENTS
HYDROGEN COMPOUNDS
IMAGES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLING
MAGNESIUM COMPOUNDS
METALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
RADIOISOTOPES
REDUCING AGENTS
SODIUM COMPOUNDS
STABLE ISOTOPES
STEROIDS
SYNTHESIS
TELLURIUM 123
TELLURIUM COMPOUNDS
TELLURIUM ISOTOPES
TRACER TECHNIQUES