Proton nuclear magnetic resonance of regenerating rat liver after partial hepatectomy
- Univ. of Rennes School of Medicine, France
Spin-lattice (T/sub 1/) and spin-spin (T/sub 2/) proton nuclear magnetic resonance relaxation times were measured over a 48-hours period of experimental liver regeneration in Wistar rats, T/sub 2/ showed an early significant increase reaching a plateau 30% above baseline from the 10th hrs onwards. Laparotomized control animals showed no change in T/sub 2/ values. The increase in T/sub 1/ occurred at a later stage but was no different from that in laparotomized controls. T/sub 1/ reached a peak, 20% above baseline, around the 30th hr. The changes observed were far less marked than those previously described for cancer tissue, which showed about a 60% increase in T/sub 1/ fluctuations followed a circadian pattern, with a minimum at night's end and a maximum around mid-day. No circadian rhythm was seen for T/sub 2/. The observed T/sub 1/ and T/sub 2/ changes are discussed with respect to mitotic and metabolic events known to occur during regeneration of the liver.
- OSTI ID:
- 6880015
- Journal Information:
- Life Sci.; (United States), Vol. 31:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LIVER
BIOLOGICAL REGENERATION
NUCLEAR MAGNETIC RESONANCE
DAILY VARIATIONS
PROTONS
RATS
SPIN-LATTICE RELAXATION
VARIATIONS
ANIMALS
BARYONS
BIOLOGICAL RECOVERY
BODY
DIGESTIVE SYSTEM
ELEMENTARY PARTICLES
FERMIONS
GLANDS
HADRONS
MAGNETIC RESONANCE
MAMMALS
NUCLEONS
ORGANS
RECOVERY
RELAXATION
RESONANCE
RODENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)