Resting early peak diastolic filling rate: a sensitive index of myocardial dysfunction in patients with coronary artery disease

Journal Article · Tue Jun 01 04:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6879916

Polak, J F; Kemper, A J; Bianco, J A; Parisi, A F; Tow, D E

Resting first-pass radionuclide angiocardiography (RNA) was used to derive left-ventricular (LV) peak diastolic filling rates (PFR) in normals (Group 1:N . 12) and in patients with coronary artery disease (CAD), both without (Group 2:N . 27) and with previous myocardial infarction (Group 3:N . 23). Resting peak filling rates were significantly depressed in both Group 2 (1.61 +/- 0.36; p less than 0.01) and Group 3 (1:35 +/- 0.26; p less than 0.001) patients when compared with Group 1, normals (2.14 +/- 0.63). Even though LV systolic function of Group 2 patients was normal and comparable to that in Group 1 (EF . 0.55 +/- 0.06 against EF 0.55 +/- 0.06 NS), diastolic dysfunction (PFR less than 1.61 end diastolic volume/sec (EDV/sec)) was present at rest in 14 of 27 (52%). Depressed PFR values was also seen in 20 of 23 Group 3 patients (87%). It appears that (a) resting PFR is a sensitive and easily obtainable parameter of the diastolic dysfunction associated with CAD; (b) abnormal PFR values are seen in almost all patients with previous myocardial damage, and (c) a significant proportion of CAD patients without any evidence of abnormal systolic function have depressed resting PFR of the LV.

• Research Organization: West Roxbury Veterans Administration Medical Center, Massachusetts
• OSTI ID: 6879916
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BIOLOGICAL FUNCTIONS
BLOOD CIRCULATION
BLOOD VESSELS
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DYNAMIC FUNCTION STUDIES
FUNCTIONS
HEART
ISOTOPE APPLICATIONS
MUSCLES
MYOCARDIUM
ORGANS
PATHOLOGY
PATIENTS
PHYSIOLOGY
RADIOCARDIOGRAPHY