Effects of nickel dust on rabbit alveolar epitheliium

Journal Article · Fri Aug 01 04:00:00 EDT 1980 · Environ. Res.; (United States)

OSTI ID:6879851

Johansson, A; Camner, P

Eight male rabbits were exposed to metallic nickel dust, during 1 month (5 days/week, 6 h/day) at a concentration of 1.7 mg/m/sup 3/ (SD 0.5), about 40% of which was respirable. Morphometric measurements on the lungs of exposed rabbits showed about a twofold increase in volume density of type II alveolar epithelial cells compared to eight controls. This increment was about the same as the average increase in phospholipids in the lung parenchyma of the rabbits described elsewhere. The volume density of lamellar bodies within the cytoplasm of the type II cell was not significantly increased. Large amounts of laminated structures, resembling those in the alveolar type II cells, were also found free in the alveoli in the exposed rabbits.

• Research Organization: Univ. of Stockholm, Sweden
• OSTI ID: 6879851
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 22:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
COLLOIDS
CONNECTIVE TISSUE CELLS
DISPERSIONS
DUSTS
ELEMENTS
EPITHELIUM
INHALATION
INTAKE
LUNGS
MACROPHAGES
MAMMALS
METALS
MORPHOLOGICAL CHANGES
NICKEL
ORGANS
PHAGOCYTES
RABBITS
RESPIRATORY SYSTEM
SOLS
SOMATIC CELLS
TISSUES
TRANSITION ELEMENTS
VERTEBRATES