Metronidazole as a radiosensitizer: a preliminary report on estimation in serum and saliva

Conference · Mon Sep 01 04:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6879682

Karim, A B.M.F.; Faber, D B; Haas, R E; Hoekstra, F H; Njo, K H

Some studies indicate the clinical benefit of hypoxic radiosensitizers in patients who are undergoing radiotherapy. Serum level of sensitizers are usualy advised; however they are very demanding on the patient. Saliva level of the sensitizers may be an alternative method. This study correlated serum level of metronidazole to the saliva level in 10 patients who were undergoing radiotherapy with the sensitizer. A change to the saliva level method appears to relieve the patients.

• Research Organization: Free Univ., Amsterdam, Netherlands
• OSTI ID: 6879682
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 6:9
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANOXIA
AZOLES
BIOLOGICAL MATERIALS
BLOOD SERUM
BODY FLUIDS
CHROMATOGRAPHY
COMPARATIVE EVALUATIONS
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
LIQUID COLUMN CHROMATOGRAPHY
MATERIALS
MEDICINE
METRONIDAZOLE
NITRO COMPOUNDS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
RADIOLOGY
RADIOSENSITIZERS
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
SALIVA
SAMPLING
SEPARATION PROCESSES
THERAPY
TIME DEPENDENCE