Metronidazole as a radiosensitizer: a preliminary report on estimation in serum and saliva

Conference · Mon Sep 01 00:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6879682

Karim, A B.M.F.; Faber, D B; Haas, R E; Hoekstra, F H; Njo, K H

Some studies indicate the clinical benefit of hypoxic radiosensitizers in patients who are undergoing radiotherapy. Serum level of sensitizers are usualy advised; however they are very demanding on the patient. Saliva level of the sensitizers may be an alternative method. This study correlated serum level of metronidazole to the saliva level in 10 patients who were undergoing radiotherapy with the sensitizer. A change to the saliva level method appears to relieve the patients.

• Research Organization: Free Univ., Amsterdam, Netherlands
• OSTI ID: 6879682
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:9
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD SERUM
COMPARATIVE EVALUATIONS
METRONIDAZOLE
SAMPLING
SALIVA
TIME DEPENDENCE
ANOXIA
LIQUID COLUMN CHROMATOGRAPHY
PATIENTS
RADIOTHERAPY
ALCOHOLS
AZOLES
BIOLOGICAL MATERIALS
BODY FLUIDS
CHROMATOGRAPHY
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
MATERIALS
MEDICINE
NITRO COMPOUNDS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOLOGY
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
SEPARATION PROCESSES
THERAPY
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
550603 - Medicine- External Radiation in Therapy- (1980-)