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The elevation of blood levels of zinc protoporphyrin in mice following whole body irradiation

Journal Article · · Blood; (United States)
OSTI ID:6878799
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Elevation of zinc protoporphyrin (ZPP) levels in the blood has served as an indicator of lead poisoning and iron deficiency anemia for many years. We have discovered that sublethal doses of whole body irradiation with x-rays also elevates ZPP 2-3-fold over normal levels. The ZPP level does not begin to increase until days 12-14 postirradiation and peaks between days 18 and 20 before returning to normal levels between days 28 and 35. Increasing the radiation dose delays the onset of the rise in ZPP, but does not affect the magnitude of the elevation. At lethal doses, ZPP elevation is not observed. Neither of the two previously described mechanisms that cause elevations of ZPP, namely iron deficiency and inhibition of ferrochelatase, are responsible for the radiation-induced elevation of ZPP. The elevation of ZPP appears to be correlated with the recovery of the hematopoietic system from radiation injury.

Research Organization:
Department of Medical Biology, University of Tennessee, Knoxville
OSTI ID:
6878799
Journal Information:
Blood; (United States), Journal Name: Blood; (United States) Vol. 63:5; ISSN BLOOA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD CHEMISTRY
BODY
CARBOXYLIC ACIDS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENZYMES
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
LEAD
LYASES
MAMMALS
METALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTOPORPHYRINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SUBLETHAL IRRADIATION
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION
ZINC COMPOUNDS