Assessing toxic effects of environmental pollutants

Book · Mon Jan 01 04:00:00 EST 1979

OSTI ID:6878646

Lee, S D; Mudd, J B

Biophysical and biochemical methods for assessing the toxicity of environmental pollutants, as well as for determining the mechanisms by which toxic chemicals act, are presented, with emphasis on the effects of air pollutants on the human lung. Toxicological research with humans and nonhuman primates is described and the difficulties of assessing human toxicity on the basis of tests using laboratory animals are discussed. Attention is given to the use of lung tissue cultures, and specific lung cell types, for the assessment of the toxicity of such environmental pollutants as cigarette smoke, primary and secondary pollutants from automobile exhaust, carbon monoxide, ozone, sulfuric acid aerosols, herbicides and pesticides. The mutagenic activity of airborne particulate organic pollutants, the effects of pollutants on cell membranes, and biomathematical modeling approaches to toxicity evaluation are also considered.

• OSTI ID: 6878646
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CHALCOGENIDES
COLLOIDS
DISPERSIONS
ENVIRONMENT
EXHAUST GASES
FLUIDS
GASEOUS WASTES
GASES
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
LUNGS
MATERIALS
MUTAGENESIS
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
PARTICLES
PARTICULATES
PESTICIDES
POLLUTANTS
POLLUTION
POPULATIONS
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
SULFURIC ACID
TOXIC MATERIALS
TOXICITY
WASTES