Effect of bilayer structure on the rates of reaction of ozone with polyunsaturated fatty acids in phosphatidylcholine liposomes
The authors work in this area has focused on the determination of rates of reaction of ozone with biological molecules to allow the evaluation of the relative risk to a molecule when ozone is breathed. Most of the data they have collected are in homogeneous solutions rather than in models of biological bilayers such as liposomes. However, they earlier compared the rate constants for reaction of ozone with oleic and linoleic acids in aqueous SDS micelles with the rate constants in homogeneous organic solutions, and the micellar environment was found to have little or no effect on the rate of ozonation. The micellar environment segregates and separates substrates, but it allows much more rapid movement of lipids from the lipophilic region to the bulk aqueous phase than is true for bilayer vesicles or biological membranes. Therefore, in this report they extend their reactivity studies to include liposomal systems in order to probe the effects of the lipid bilayer structure on the reactivity of PUFA esters toward ozone.
- Research Organization:
- Louisiana State Univ., Baton Rouge (USA)
- OSTI ID:
- 6877878
- Journal Information:
- Chem. Res. Toxicol.; (United States), Journal Name: Chem. Res. Toxicol.; (United States) Vol. 1:3; ISSN CRTOE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AQUEOUS SOLUTIONS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
DISPERSIONS
ESTERS
LIPIDS
LIPOSOMES
MEMBRANES
MIXTURES
MOLECULAR STRUCTURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANOIDS
OZONE
PHOSPHOLIPIDS
SOLUTIONS
STRUCTURE-ACTIVITY RELATIONSHIPS