Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations
- Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD (United States)
- Johns Hopkins School of Hygiene, Baltimore, MD (United States)
- Allergologisk (ALK) Laboratorium A/S, Horsholm (Denmark)
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (lgE) concentration. No linkage was found between these markers and specific lgE antibody concentrations. Analysis of total lgE within a subset of 128 lgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1., especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates lgE production in a nonantigen-specific (noncognate) fashion. 37 refs., 2 figs., 2 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 68726
- Journal Information:
- Science, Vol. 264, Issue 5162; Other Information: PBD: 20 May 1994
- Country of Publication:
- United States
- Language:
- English
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