Comparative mapping of the actin-binding protein 280 genes in human and mouse

Journal Article · Sun May 15 04:00:00 EDT 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1288· OSTI ID:6872506

Gariboldi, M; Canzian, F; Manenti, G; De Gregorio, L ^[1]; Maestrini, E; Rivella, S ^[2]; Chatterjee, A; Herman, G E ^[3]; Archidiacono, N; Antonacci, R ^[4]

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1. Istituto Nazionale Tumori, Milan (Italy)
2. Istituto di Genetica Biochimica ed Evoluzionistica, Pavia (Italy)
3. Universita di Bari (Italy)
4. Institute for Molecular Genetics, Houston, TX (United States); and others

Two genes encode actin-binding protein 280 isoforms. ABP-280 or filamin (FLN1) is present in the cytoskeleton of many cell types, whereas expression of FLN2 is limited to skeletal muscle and heart. FLN1 maps to human chromosome Xq28, and, by physical mapping in YAC clones, the authors have mapped the homologous murine locus (Fln1) to mouse chromosome X, in a region of syntenic homology with human chromosome X. They mapped FLN2 to human chromosome 7q32-q35 by analysis of somatic cell hybrids containing portions of chromosome 7, and, by using a mapping panel from an interspecific murine cross, they mapped the corresponding murine locus (Fln2) to murine chromosome 6 in a region homologous to human chromosome 7. 21 refs., 1 fig., 1 tab.

• OSTI ID: 6872506
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 21:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BODY
CHROMOSOMES
GENETIC MAPPING
HETEROCHROMOSOMES
HUMAN CHROMOSOME 7
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
MAPPING
ORGANS
SKELETON
X CHROMOSOME