Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q
- Univ. of Texas Southwestern Medical Center, Dallas, TX (United States)
- Baylor Univ. Medical Center, Dallas, TX (United States); and others
A gene involved in psoriasis susceptibility was localized to the distal region of human chromosomes 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that is some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus. 28 refs., 2 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 68725
- Journal Information:
- Science, Vol. 264, Issue 5162; Other Information: PBD: 20 May 1994
- Country of Publication:
- United States
- Language:
- English
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