Radiosensitivity of fibroblasts obtained from a cafe-au-lait spot and normal-appearing skin of a patient with neurofibromatosis (NF-6)
Journal Article
·
· Cancer Genetics and Cytogenetics; (USA)
- King Faisal Specialist Hospital and Research Centre, Riyadh (Saudi Arabia)
Fibroblast cells derived from a cafe-au-lait spot and normal-appearing skin of a neurofibromatosis (NF-6) patient were studied for radiosensitivity in comparison with two normal cell lines used as controls. No difference in radiosensitivity was observed between the patient's cell lines and the controls using acute gamma-irradiation. However, a markedly increased radiosensitivity of the fibroblasts obtained from the patient's skin of normal appearance was demonstrated after chronic gamma-irradiation. The cells from the cafe-au-lait spot showed intermediate sensitivity to chronic irradiation as compared with the control cell lines and the fibroblasts derived from the normal skin of the patient. These results showed the usefulness of chronic irradiation in detecting increased cellular radiosensitivity which may result from a unique DNA repair defect in an NF patient. We suggest that enhanced genetic changes in radiosensitive NF patients may lead to formation of cafe-au-lait lesions and certain tumors. Such a transformation may be associated with production of radiotolerant cells.
- OSTI ID:
- 6869884
- Journal Information:
- Cancer Genetics and Cytogenetics; (USA), Journal Name: Cancer Genetics and Cytogenetics; (USA) Vol. 47:2; ISSN 0165-4608; ISSN CGCYD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CHRONIC EXPOSURE
CHRONIC IRRADIATION
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
DOSES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MAN
NEOPLASMS
ORGANS
PATIENTS
PRIMATES
RADIATION DOSES
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SKIN
SOMATIC CELLS
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CHRONIC EXPOSURE
CHRONIC IRRADIATION
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPAIR
DOSES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MAN
NEOPLASMS
ORGANS
PATIENTS
PRIMATES
RADIATION DOSES
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SKIN
SOMATIC CELLS
SURVIVAL TIME
TUMOR CELLS
VERTEBRATES