Quinolone therapy of Klebsiella pneumoniae sepsis following irradiation: Comparison of pefloxacin, ciprofloxacin, and ofloxacin
- Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
Exposure to whole-body irradiation is associated with fatal gram-negative sepsis. The effect of oral therapy with three quinolones, pefloxacin, ciprofloxacin, and ofloxacin, for orally acquired Klebsiella pneumoniae infection was tested in B6D2F1 mice exposed to 8.0 Gy whole-body irradiation from bilaterally positioned 60Co sources. A dose of 10(8) organisms was given orally 2 days after irradiation, and therapy was started 1 day later. Quinolones reduced colonization of the ileum with K. pneumoniae: 16 of 28 (57%) untreated mice harbored the organisms, compared to only 12 of 90 (13%) mice treated with quinolones (P less than 0.005). K. pneumoniae was isolated from the livers of 6 of 28 untreated mice, compared to only 1 of 90 treated mice (P less than 0.001). Only 5 of 20 (25%) untreated mice survived for at least 30 days compared with 17 of 20 (85%) mice treated with ofloxacin, 15 of 20 (75%) mice treated with pefloxacin, and 14 of 20 (70%) treated with ciprofloxacin (P less than 0.05). These data illustrate the efficacy of quinolones for oral therapy of orally acquired K. pneumoniae infection in irradiated hosts.
- OSTI ID:
- 6867826
- Journal Information:
- Radiation Research; (USA), Vol. 122:2; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BACTERIAL DISEASES
CHEMOTHERAPY
RADIOPROTECTIVE SUBSTANCES
EVALUATION
COBALT 60
KLEBSIELLA
MICE
ORAL ADMINISTRATION
RADIATION INJURIES
RADIOSENSITIVITY EFFECTS
WHOLE-BODY IRRADIATION
ANIMALS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT ISOTOPES
DISEASES
DRUGS
EXTERNAL IRRADIATION
INFECTIOUS DISEASES
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
THERAPY
VERTEBRATES
YEARS LIVING RADIOISOT
560152* - Radiation Effects on Animals- Animals