Neurotoxic behavioral effects of Lake Ontario salmon diets in rats
Journal Article
·
· Neurotoxicology and Teratology; (USA)
- State Univ. of New York, Oswego (USA)
Six experiments were conducted to examine possible neurotoxic effects of the exposure to contaminants in Lake Ontario salmon administered through the diets of rats. Rats were fed different concentrations of fish (8%, 15% or 30%) in one of three diet conditions: Lake Ontario salmon, Pacific Ocean salmon, or laboratory rat chow only. Following 20 days on the diets, rats were tested for five minutes per day in a modified open field for one or three days. Lake Ontario salmon diets consistently produced significantly lower activity, rearing, and nosepoke behaviors in comparison with ocean salmon or rat chow diet conditions. A dose-response effect for concentration of lake salmon was obtained, and the attenuation effect occurred in males, females, adult or young animals, and postweaning females, with fish sampled over a five-year period. While only two of several potential contaminants were tested, both fish and brain analyses of mirex and PCBs relate to the behavioral effects.
- OSTI ID:
- 6867274
- Journal Information:
- Neurotoxicology and Teratology; (USA), Journal Name: Neurotoxicology and Teratology; (USA) Vol. 12:2; ISSN 0892-0362; ISSN NETEE
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of Great Lakes fish consumption on brain PCB pattern, concentration, and progressive-ratio performance
Ingestion of environmentally contaminated Lake Ontario salmon by laboratory rats increases avoidance of unpredictable aversive nonreward and mild electric shock
PCB congener patterns in rats consuming diets containing Great Lakes salmon: Analysis of fish, diets, and adipose tissue
Journal Article
·
Fri Dec 31 23:00:00 EST 1999
· Environmental Research
·
OSTI ID:20026669
Ingestion of environmentally contaminated Lake Ontario salmon by laboratory rats increases avoidance of unpredictable aversive nonreward and mild electric shock
Journal Article
·
Thu Nov 30 23:00:00 EST 1989
· Behavioral Neuroscience; (USA)
·
OSTI ID:6991547
PCB congener patterns in rats consuming diets containing Great Lakes salmon: Analysis of fish, diets, and adipose tissue
Journal Article
·
Sun Jan 31 23:00:00 EST 1999
· Environmental Research
·
OSTI ID:355617
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANADROMOUS FISHES
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BEHAVIOR
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CONTAMINATION
DIET
FISHES
FOOD CHAINS
FRESH WATER
GREAT LAKES
HYDROCARBONS
HYDROGEN COMPOUNDS
LAKE ONTARIO
LAKES
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
RODENTS
SALMON
SURFACE WATERS
TOXICITY
VERTEBRATES
WATER
WATER POLLUTION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANADROMOUS FISHES
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BEHAVIOR
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CONTAMINATION
DIET
FISHES
FOOD CHAINS
FRESH WATER
GREAT LAKES
HYDROCARBONS
HYDROGEN COMPOUNDS
LAKE ONTARIO
LAKES
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
POLLUTION
POLYCYCLIC AROMATIC HYDROCARBONS
RATS
RODENTS
SALMON
SURFACE WATERS
TOXICITY
VERTEBRATES
WATER
WATER POLLUTION