Autologous bone marrow transplantation following chemotherapy and irradiation in dogs with spontaneous lymphomas. [. gamma. rays]

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6867205

Bowles, C A ^[1]; Bull, M; McCormick, K; Kadin, M; Lucas, D

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1. Hazleton Labs. of America, Vienna, VA

Thirty dogs with spontaneous lymphomas were administered two to six cycles of chemotherapy and were randomized into 3 groups to receive 800 rads of total body irradiation and autologous bone marrow transplantation. Of 10 dogs irradiated after chemotherapy-induced remission and infused with remission marrow (group 1), 8 (80%) had successful grafts and experienced remissions lasting 62 to 1024 days. Of 9 dogs irradiated during remission and infused with remission marrow mixed with autologous tumor cells (group 2), 6 (66%) had remission lasting 15 to 45 days. Eleven dogs with progressive tumor growth (relapse) following chemotherapy were irradiated and infused with remission marrow (group 3). Tumor remission lasting 39 to 350 days was observed in 5 dogs (45%) in this group, and 6 dogs died in less than 30 days. Dogs in groups 1 to 3 had median survival times of 216, 60, and 45 days, respectively. The prolonged survival times for dogs in group 1 compared to dogs in groups 2 and 3 suggest that protocols involving irradiation and autologous marrow grafting in this model would be most effective when these protocols are applied to animals having a minimum tumor burden at the time of irradiation and when the grafting is done with tumor-free autologous marrow.

• OSTI ID: 6867205
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 65:3; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ALKALOIDS
ALKYLATING AGENTS
AMINES
ANIMAL TISSUES
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CHEMOTHERAPY
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
CORTICOSTEROIDS
DISEASES
DOGS
DRUGS
ELECTROMAGNETIC RADIATION
ENZYMES
EXTERNAL IRRADIATION
GAMMA RADIATION
GLUCOCORTICOIDS
GRAFTS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROLASES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LEUKOCYTES
LYMPHOMAS
MAMMALS
MATERIALS
MEDICINE
MERCAPTOPURINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NITROGEN MUSTARD
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ONCOVIN
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PERFORMANCE
PREDNISONE
PREGNANES
PURINES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
STEROID HORMONES
STEROIDS
SURVIVAL TIME
THERAPY
THIOLS
TISSUES
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES