Acid air pollutant mixtures: Respiratory system responses and effects of exercise
The study involved evaluation of rats exposed (at rest or while exercising) via a nose-only exposure system to various combinations of pollutants. The duration of exposure was four hours. The effects of O3 alone were compared to a combination of O3, HNO3 and H2SO4 and to a combination of O3 and HMSA. The comparisons were made at two concentration levels. Target concentrations for the lower levels were 0.20 ppm O3, 0.50 mg/cu m HNO3, 0.25 mg/cu m H2SO4 and 0.25 mg/cu m HMSA while higher concentration levels were twice these values. The toxic effects evaluation included: (1) Pulmonary function measures consisting of breathing frequency, tidal volume, minute ventilation, oxygen consumption, ventilation equivalent for oxygen and body temperature; (2) Histopathological analysis of nasal and lung epithelium which included: (a) microscopic analysis of nasal and lung tissue sections for qualitative analysis of injury and quantifying the injury as lesion areas; and (b) measurement of cell turnover by autoradiography as evidence of injury to the lining epithelium; (3) Biochemical analysis of pulmonary surfactant (PS) by Fourier transform infrared spectrometry (FTIR), ultraviolet spectrometry and gas chromatographic analysis for fatty acid composition of the PS.
- Research Organization:
- California Univ., Irvine, CA (USA). Dept. of Community and Environmental Medicine
- OSTI ID:
- 6864549
- Report Number(s):
- PB-90-245077/XAB; CNN: ARB-A6-148-33
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of nitric acid vapor alone, and in combination with ozone, in exercising, healthy subjects as assessed by bronchoalveolar and proximal lavage. Final report
Alterations in lung structure caused by inhalation of oxidants. [Rats]
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL TISSUES
AUTORADIOGRAPHY
BODY
CARBOXYLIC ACIDS
CHROMATOGRAPHY
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EPITHELIUM
EXERCISE
FOURIER ANALYSIS
GAS CHROMATOGRAPHY
HYDROGEN COMPOUNDS
INORGANIC ACIDS
MIXTURES
NITRIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
OZONE
POLLUTION
RESPIRATORY SYSTEM
SENSITIVITY
SEPARATION PROCESSES
SPECTRA
SULFURIC ACID
SYNERGISM
TISSUES
TOXICITY
ULTRAVIOLET SPECTRA