The role of elf field dosimetry and bioeffects mechanisms in relating in vitro to in vivo exposures

Conference · Fri Jun 01 00:00:00 EDT 1990

OSTI ID:6864525

Miller, D L

Animal exposures to ELF electric or magnetic fields are typically described in terms of the external field direction and RMS magnitude. Within the animal, the magnetic field exists virtually unperturbed by the body, while the external electric field is greatly attenuated. In addition, electrical fields and currents are induced inside any conducting body exposed to ELF electric or magnetic fields, and these are strongly dependent on the size, shape and conductivity of the object. In vitro, similar considerations apply to the volume of cell suspension, but a greater degree of control is possible in the relative magnitudes of electric field, induced current and magnetic field in the media. The goal of this presentation is to outline general aspects of this interaction and to compare the biophysical dosimetry for animals to the situation which pertains for in vitro experiments. Such information is critical for rational development of exposure systems and selection of appropriate exposure parameters. Since one major objective of in vitro experiments is to simulate the bioeffects situation in vivo, dosimetric information is needed for any extrapolation of laboratory in vitro or animal experimental results to environmental exposures of humans. In addition, this information is needed for the consideration of potential mechanisms of biological effects of ELF fields. 7 refs., 3 figs., 1 tab.

• Research Organization: Pacific Northwest Lab., Richland, WA (USA)
• Sponsoring Organization: DOE/CE
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6864525
• Report Number(s): PNL-SA-18290; CONF-9006269-1; ON: DE90017240
• Resource Relation: Conference: 12. annual meeting of the bioelectromagnetics society, San Antonio, TX (USA), 10-14 Jun 1990
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
24 POWER TRANSMISSION AND DISTRIBUTION
ELECTRIC FIELDS
HEALTH HAZARDS
ELECTROMAGNETIC FIELDS
BIOLOGICAL EFFECTS
ANIMALS
CURRENT DENSITY
HUMAN FACTORS
HVAC SYSTEMS
MAGNETIC FIELDS
MAN
MAXIMUM PERMISSIBLE EXPOSURE
MEASURING METHODS
POWER DISTRIBUTION SYSTEMS
POWER TRANSMISSION LINES
PUBLIC HEALTH
RISK ASSESSMENT
AC SYSTEMS
ENERGY SYSTEMS
HAZARDS
MAMMALS
POWER SYSTEMS
PRIMATES
SAFETY STANDARDS
STANDARDS
VERTEBRATES
560400* - Other Environmental Pollutant Effects
240500 - Power Transmission & Distribution- Environmental Aspects- (1990-)