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Distribution and elimination of (/sup 14/C)octachlorostyrene in cod (Gadus morhua), rainbow trout (Salmo gairdneri, and blue mussel (Mytilus edulis)

Journal Article · · J. Toxicol. Environ. Health; (United States)
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Cod (Gadus morhua) and rainbow trout (Salmo gairdneri) were given a single oral dose of 100 microCi/kg b.w. of (/sup 14/C)octachlorostyrene ((/sup 14/C)OCS) in peanut oil. Blue mussel (Mytilus edulis) was exposed to (/sup 14/C)OCS in water. The distribution and elimination of the compound was studied by liquid scintillation counting and whole-body autoradiography. The highest degree of radioactivity in the cod and rainbow trout was measured in the liver and the visceral fat, respectively. The degree of radioactivity in the brain of cod exceeded that of the rainbow trout by a factor between 2 and 4 at all survival times. In addition to bile excretion of (/sup 14/C)OCS-derived radioactivity, a possible excretion over the intestinal mucosa was suggested. The rate of elimination was slow in both species, and substantial amounts of radioactivity remained in the tissues 90 d after administration. In the blue mussel, the highest degree of radioactivity was found in the hepatopancreas. Substantial amounts of radioactivity were present in the mussel tissues 60 d after administration.

Research Organization:
Norwegian College of Veterinary Medicine, Oslo
OSTI ID:
6864440
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 25:3; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATED AROMATICS
ANIMALS
AQUATIC ORGANISMS
AROMATICS
AUTORADIOGRAPHY
BIOLOGICAL VARIABILITY
BODY
CARBON 14 COMPOUNDS
COUNTING TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
FISHES
GENETIC VARIABILITY
GLANDS
HYDROCARBONS
INVERTEBRATES
LABELLED COMPOUNDS
LIVER
METABOLISM
MOLLUSCS
MUSSELS
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
SCINTILLATION COUNTING
STYRENE
TISSUE DISTRIBUTION
TROUT
VERTEBRATES