Effects of E-64, a cysteine proteinase inhibitor, on cowpea weevil growth, development, and fecundity

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Environ. Entomol.; (United States)

DOI:https://doi.org/10.1093/ee/17.3.467· OSTI ID:6864325

Murdock, L L; Shade, R E; Pomeroy, M A

E-64, a specific inhibitor of cysteine proteinases, was incorporated into artificial seeds at low levels (0.01-0.25% by weight). It prolonged developmental time and increased mortality of the larval cowpea weevil, Callosobruchus maculatus (F.), in direct proportion to its concentration in the artificial seeds. The fecundity of females emerging from the artificial seeds was significantly decreased by E-64 concentrations of 0.06% and higher. These observations are compatible with the hypothesis that the midgut cysteine proteinase in C. maculatus is essential for normal growth and development.

• Research Organization: Purdue Univ., West Lafayette, IN (USA)
• DOE Contract Number: AC02-80ER10715
• OSTI ID: 6864325
• Journal Information: Environ. Entomol.; (United States), Vol. 17:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BEETLES
GROWTH
ENZYME INHIBITORS
BIOLOGICAL EFFECTS
CYSTEINE
DIET
LARVAE
METABOLISM
PEPTIDE HYDROLASES
SEEDS
AMINO ACIDS
ANIMALS
ARTHROPODS
CARBOXYLIC ACIDS
COLEOPTERA
ENZYMES
HYDROLASES
INSECTS
INVERTEBRATES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
THIOLS
550500* - Metabolism