Clinical, toxicological, and pathological aspects of arsanilic acid poisoning in swine

Journal Article · Sun Dec 31 23:00:00 EST 1972 · Clin. Toxicol.; (United States)

DOI:https://doi.org/10.3109/15563657308990543· OSTI ID:6863250

Ledet, A E; Duncan, J R; Buck, W B; Ramsey, F K

In Trial I, toxicosis was induced in 27 pigs by feeding 1000 ppM arsanilic acid in the ration. The clinical syndrome was first characterized by transient diarrhea and incoordination, with posterior paresis and quadriplegia later. Detectable histopathological changes were confined to the optic tracts, optic nerves, and peripheral nerves. Major lesions noted were necrosis of myelin-supporting cells and degeneration of myelin sheaths and axons. Maximum mean arsenic levels were present in liver, kidney, skeletal muscle, rib, and blood on or before day 13 of the experiment. Maximum mean arsenic levels in the nervous system were not attained until days 19 and 21. In Trial II, six pigs were fed 1000 ppM arsanilic acid in the ration for 19 days. Three days after the removal of dietary arsanilic acid, skeletal muscle, kidney, liver, and blood, respectively, retained 31, 34, 32, and 13 mean % of the tissue arsenic present at the time of drug withdrawal. Nervous tissue retained 100, 93, 57 mean % arsenic 3, 6, and 11 days post-withdrawal, respectively. In Trial III, six pigs were fed 1000 ppM arsanilic acid in the ration until they developed severe posterior paresis or quadriplegia. Four pigs had no clinical improvement and two pigs developed a more severe paralysis after withdrawal of the drug. 12 references, 10 figures, 5 tables.

• Research Organization: Iowa State Univ., Ames
• OSTI ID: 6863250
• Journal Information: Clin. Toxicol.; (United States), Journal Name: Clin. Toxicol.; (United States) Vol. 6:3; ISSN CTOXA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL TISSUES
ANIMALS
ANTIGENS
ARSANILIC ACID
ARSENIC
ARSENIC COMPOUNDS
ARSONIC ACIDS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
DIET
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ECOLOGICAL CONCENTRATION
ELEMENTS
GLANDS
KIDNEYS
LIVER
MAMMALS
MATERIALS
NECROSIS
NERVE TISSUE
ORGANIC ACIDS
ORGANIC ARSENIC COMPOUNDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
SEMIMETALS
SKELETON
SWINE
TISSUES
TOXIC MATERIALS
TOXICITY
TOXINS
VERTEBRATES