Increased pulmonary alveolar-capillary permeability in patients at risk for adult respiratory distress syndrome
Two methods for predicting adult respiratory distress syndrome (ARDS) were evaluated prospectively in a group of 81 multitrauma and sepsis patients considered at clinical high risk. A popular ARDS risk-scoring method, employing discriminant analysis equations (weighted risk criteria and oxygenation characteristics), yielded a predictive accuracy of 59% and a false-negative rate of 22%. Pulmonary alveolar-capillary permeability (PACP) was determined with a radioaerosol lung-scan technique in 23 of these 81 patients, representing a statistically similar subgroup. Lung scanning achieved a predictive accuracy of 71% (after excluding patients with unilateral pulmonary contusion) and gave no false-negatives. We propose a combination of clinical risk identification and functional determination of PACP to assess a patient's risk of developing ARDS.
- Research Organization:
- Univ. of Cincinnati College of Medicine, OH
- OSTI ID:
- 6863105
- Journal Information:
- Crit. Care Med.; (United States), Journal Name: Crit. Care Med.; (United States) Vol. 4; ISSN CCMDC
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ADULTS
AGE GROUPS
AMINO ACIDS
BLOOD VESSELS
BODY
CAPILLARIES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
COUNTING TECHNIQUES
DIAGNOSIS
DISEASES
DRUGS
DTPA
ELEMENTS
FORECASTING
LUNGS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
PATIENTS
PERMEABILITY
RADIOISOTOPE SCANNING
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RISK ASSESSMENT
TECHNETIUM
TRANSITION ELEMENTS