Quantitative analysis of benzene by selected ion monitoring/gas chromatography/mass spectrometry
A selected ion monitoring gas chromatographic/mass spectrometric method for the quantitative determination of benzene in air, breath, and blood was developed utilizing a headspace assay with benzene-d/sub 3/ as an internal standard. Limits of detection for 2 ng/mL in blood and 0.1 ppb in a 5-L sample of air or breath were attained. The influence of contamination by background benzene on the analytical process was studied carefully. For cases where background contamination could not be adequately controlled, the assay was modified for the quantitative determination of labelled benzenes six mass units heavier than natural benzene (benzene-d/sub 6/ or benzene-/sup 13/C/sub 6/). Use of the method for the analysis of natural benzene was illustrated for the measurement of background levels in urban smokers and nonsmokers.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 6862115
- Journal Information:
- J. Anal. Toxicol.; (United States), Journal Name: J. Anal. Toxicol.; (United States) Vol. 10:6; ISSN JATOD
- Country of Publication:
- United States
- Language:
- English
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54 ENVIRONMENTAL SCIENCES
550500 -- Metabolism
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AROMATICS
BENZENE
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBON 13
CARBON ISOTOPES
CHEMICAL ANALYSIS
CHROMATOGRAPHY
COLLOIDS
DISPERSIONS
EVEN-ODD NUCLEI
GAS CHROMATOGRAPHY
HYDROCARBONS
ISOTOPES
LIGHT NUCLEI
MASS SPECTROSCOPY
MATERIALS
METABOLISM
MONITORING
NUCLEI
ORGANIC COMPOUNDS
RESIDUES
SEPARATION PROCESSES
SMOKES
SOLS
SPECTROSCOPY
STABLE ISOTOPES
TOBACCO SMOKES