Irradiation of meningiomas of the intracranial anterior visual pathway

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410210205· OSTI ID:6860403

Kupersmith, M J; Warren, F A; Newall, J; Ransohoff, J

Twenty patients with progressive visual loss caused by intracranial meningiomas involving the anterior visual pathway were treated with irradiation alone (n = 4) or with irradiation combined with tumor excision (n = 16). Improvement in visual performance occurred in 13 patients; 2 patients experienced temporary improvement; and 5 others maintained stable visual function for up to 9.5 years (mean follow-up, 4.0 years). Radiotherapy seemed to have no effect in 2 patients. One patient experienced temporary improvement, but eventually died from spread of tumor. Only one definite complication of radiotherapy occurred and was related to excessive radiation dose (greater than 7,000 cGy). Irradiation in the range of 5,000 to 5,500 cGy was effective either alone or in combination with surgical excision. Serial assessment of visual acuity and fields allowed us to demonstrate and quantify improvement in our patients following radiotherapy; in contrast, follow-up computed tomographic studies rarely demonstrated reduced tumor size.

• Research Organization: New York Univ. Medical Center, NY
• OSTI ID: 6860403
• Journal Information: Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 2; ISSN ANNED
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
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62 RADIOLOGY AND NUCLEAR MEDICINE
COMBINED THERAPY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DOSES
MEDICINE
MEMBRANES
MENINGES
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
SURGERY
THERAPY
TOMOGRAPHY