Prediction of infarct volume in patients undergoing reperfusion therapy by Tc-99m antimyosin SPECT
The predictability of infarct volume by Tc-99m antimyosin SPECT was evaluated within 24 hours of chest pain and this was compared to the length of akinesis (AK) from the pre-discharge left ventriculogram (LVgram). Ten patients (pts) with acute myocardial infarction who underwent streptokinase thrombolytic therapy (success 8, failure 2) were subjects of this investigation. None had previous infarction. Average reperfusion time was within 4.5 hours and 20mCi of Tc-99m antimyosin was given intravenously within 8 hours after chest pain; SPECT imaging was performed within 18 hours after injection. Infarct volume was calculated from SPECT and expressed as grams of myocardial infarction (GMI). Ten days later, a 30/sup 0/RAO contrast LVgram was recorded and the length of AK (corrected for magnification) was measured along the LV border at the end-diastolic phase and expressed as cm of AK. GMI and AK were measured independently without knowledge of each other. Results are given. The data demonstrate a good correlation of GMI and AK. Infarct volume can be measured by antimyosin SPECT within 24 hours of chest pain and predict residual LV dysfunction in pts undergoing reperfusion therapy.
- Research Organization:
- Massachusetts General Hospital, Boston, MA
- OSTI ID:
- 6859231
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEST
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
EVALUATION
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOCARDIOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
TECHNETIUM ISOTOPES
THERAPY
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES