Method for estimating the systemic burden of Pu from urinalyses

Journal Article · Sun Mar 01 00:00:00 EST 1987 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198703000-00008· OSTI ID:6857896

Leggett, R W; Eckerman, K F

It is generally agreed that Langham's model for urinary excretion of Pu substantially overestimates the systemic burden several years after exposure. Improved estimates can be derived from information obtained since the development of that model, including comparative urine and autopsy data for occupationally exposed persons; reanalyzed and updated data for human subjects injected with Pu; and a large body of general physiological and Pu-specific information on the processes governing the behavior of Pu in the body. We examine modeling approaches based on each of these sets of information and show that the three approaches yield fairly consistent estimates of the urinary excretion rate over three decades after contamination of blood. Estimates from the various approaches are unified to obtain a single set of predicted urinary excretion rates that, in effect, is based on all three bodies of information. A simple method is described for using these excretion rates to estimate intakes and systemic burdens of Pu.

• Research Organization: Oak Ridge National Lab., TN
• OSTI ID: 6857896
• Journal Information: Health Phys.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PLUTONIUM
BODY BURDEN
URINE
RADIONUCLIDE KINETICS
AUTOPSY
BIOLOGICAL MODELS
ENVIRONMENTAL EXPOSURE
EXCRETION
ACTINIDES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CLEARANCE
DIAGNOSTIC TECHNIQUES
ELEMENTS
MATERIALS
METALS
TRANSURANIUM ELEMENTS
WASTES
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man