Lithium: effect on (/sup 3/H)spiperone binding, ionic content, and amino acid levels in the brain of rats

Journal Article · Mon Feb 01 04:00:00 EST 1982 · Neurochem. Res.; (United States)

DOI:https://doi.org/10.1007/BF00965056· OSTI ID:6857489

Banay-Schwartz, M; Wajda, I J; Manigault, I; DeGuzman, T; Lajtha, A

After prolonged treatment of rats with lithium (pellets, 0.21% lithium carbonate, or 0.5 mg/ml lithium chloride in drinking water) for three months, the level of lithium in plasma was 0.87 meq/liter; in several brain regions, between 1.06-1.39 mueq/g wet weight. The content of sodium and potassium in the plasma was normal. The level of potassium in the brain regions tested increased by 13-30% and that of sodium by about 10%. Glycine levels increased significantly in all the regions (cerebral cortex, midbrain, cerebellum, and spinal cord). In the cerebellum GABA was also increased, while glutamine was decreased. In midbrain, apart from increases in glycine levels, alanine, valine, GABA and lysine were also increased. In the spinal cord, glutamic acid was also increased. Changes were largely in the putative neurotransmitters. Long-term treatment with lithium also influenced the high-affinity binding of (/sup 3/H) spiperone in the cerebral cortex and corpus striatum. Two specific binding sites were found in both brain regions; the main change was the reduction in the lower affinity binding site (B max 2).

• Research Organization: Center for Neurochemistry, Rockland Research Institute, Ward's Island, NY
• OSTI ID: 6857489
• Journal Information: Neurochem. Res.; (United States), Journal Name: Neurochem. Res.; (United States) Vol. 7:2; ISSN NERED
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALANINES
ALKALI METAL COMPOUNDS
AMIDES
AMINO ACIDS
AMINOBUTYRIC ACID
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
BRAIN
CARBON COMPOUNDS
CARBONATES
CARBOXYLIC ACIDS
CATIONS
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBRAL CORTEX
CEREBRUM
CHARGED PARTICLES
CHLORIDES
CHLORINE COMPOUNDS
DRINKING WATER
DRUGS
GLUTAMIC ACID
GLUTAMINE
GLYCINE
HALIDES
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
IONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LITHIUM CARBONATES
LITHIUM CHLORIDES
LITHIUM COMPOUNDS
LITHIUM HALIDES
LYSINE
MAMMALS
MATERIALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
POTASSIUM COMPOUNDS
RATS
RECEPTORS
RODENTS
SODIUM COMPOUNDS
SPINAL CORD
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VALINE
VERTEBRATES
WATER