Possible distortion of antibody binding site of the Mcg Bence-Jones protein by lattice forces
Journal Article
·
· Biophys. J.; (United States)
The Mcg Bence-Jones protein dimer closely resembles an antigen binding fragment of a functional antibody molecule both in its structure and function. It consists of two chemically identical light chains which have different conformations: monomer 1 resembles the heavy chain, and monomer 2 the light chain of an Fab fragment. Each monomer consists of a variable and a constant domain connected by a switch peptide. In the crystal, the two variable domains, and also the two constant domains, have very similar structures related by local twofold axes. However, because the symmetry is only a local one, the surface of the domains is influenced by their different environments in the crystal.
- Research Organization:
- Argonne National Lab., IL
- OSTI ID:
- 6856996
- Journal Information:
- Biophys. J.; (United States), Journal Name: Biophys. J.; (United States) Vol. 32:1; ISSN BIOJA
- Country of Publication:
- United States
- Language:
- English
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