Kinetics of the T4 gene 32 protein-single-stranded nucleic acid interaction
Journal Article
·
· Biophys. J.; (United States)
The kinetics of the interaction of the T4 bacteriophage coded gene 32 protein (GP32) with single-stranded nucleic acids have been investigated. The GP32 is a helix destablizing protein necessary for DNA replication, recombination, and repair. GP32 functions through its interaction with single-stranded DNA and RNA to which it binds cooperatively. Its main function during replication is thought to be the stabilization of transient single-stranded regions in the replication fork. Kinetic studies are necessary to understand how GP32 interacts with a moving replication fork.
- Research Organization:
- Univ. of California, San Diego
- OSTI ID:
- 6856681
- Journal Information:
- Biophys. J.; (United States), Journal Name: Biophys. J.; (United States) Vol. 32:1; ISSN BIOJA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
550400 -- Genetics
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
BACTERIOPHAGES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONFIGURATION
DNA
DNA REPLICATION
HELICAL CONFIGURATION
KINETICS
MICROORGANISMS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PROTEINS
REACTION KINETICS
RECOVERY
REPAIR
RNA
VIRUSES
550400 -- Genetics
550700 -- Microbiology
59 BASIC BIOLOGICAL SCIENCES
BACTERIOPHAGES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONFIGURATION
DNA
DNA REPLICATION
HELICAL CONFIGURATION
KINETICS
MICROORGANISMS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PROTEINS
REACTION KINETICS
RECOVERY
REPAIR
RNA
VIRUSES