Self-assembly of tobacco mosaic virus: influence of the viral RNA and protein components upon the assembly process

Journal Article · Wed Oct 01 00:00:00 EDT 1980 · Biophys. J.; (United States)

DOI:https://doi.org/10.1016/S0006-3495(80)84983-6· OSTI ID:6856677

Hirth, L; Lebeurier, G; Nicolaieff, A; Richards, K E

The initial stage in the self-assembly of tobacco mosaic virus (TMV) RNA and coat protein into virions involves insertion of a loop of TMV RNA between layers of a double-layered disk of TMV protein (containing 17 coat protein subunits per layer) via the central channel of the disk, followed by conversion of the disk-RNA complex into a two-turn protohelix and addition of more protein (elongation). This mechanism leads to assembling particles in which one of the uncoated RNA tails, that containing the 5'-terminus, runs back along the central channel of the growing rod.

• Research Organization: Institut de Biologie Moleculaire et Cellulaire, Strasbourg, FR
• OSTI ID: 6856677
• Journal Information: Biophys. J.; (United States), Journal Name: Biophys. J.; (United States) Vol. 32:1; ISSN BIOJA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
550700 -- Microbiology
550800 -- Morphology
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
KINETICS
MEMBRANES
MICROORGANISMS
MOLECULAR STRUCTURE
MORPHOLOGY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
REACTION KINETICS
RNA
STRUCTURAL CHEMICAL ANALYSIS
SYNTHESIS
TOBACCO MOSAIC VIRUS
VIRUSES