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Title: Radionuclide imaging of myocardial infarction using Tc-99m TBI

Abstract

The cationic complex Tc-99m t-butylisonitrile (TBI) concentrates in the myocardial tissue of several animal species. Its myocardial distribution is proportional to blood flow both in zones of ischemia and in normal myocardium at rest. Planar, tomographic, and gated myocardial images have been obtained using Tc-99m TBI in the human. The authors investigated the potential application of Tc-99m TBI imaging to detect and localize myocardial infarction. Four subjects without clinical evidence of cardiovascular disease and five patients with ECG evidence of previous myocardial infarction were studied. Tc-99m TBI (10mCi) was injected intravenously with the patient in a resting state with planar imaging in the anterior, 30 and 70 degree LAO projections beginning one hr after injection. The distribution of the tracer was homogeneous throughout the left ventricular wall in the normal subjects. Regional perfusion defects were present in 4/5 of the patients with myocardial infarction. Location of the defects corresponded to the location of the infarct using ECG criteria (2 inferoposterior and 2 anterior). The patient in whom the Tc-99m TBI image appeared normal had sustained a subendocardial myocardial infarct which could not be localized by ECG; the other 4 pts had transmural infarcts. Anterior and 30 degree LAO images weremore » of excellent quality in all cases; there was overlap of the liver on the inferior wall of the left ventricle on the 70 degree LAO views. The authors conclude that accurate perfusion imaging may be possible using Tc-99m TBI in patients with transmural myocardial infarction.« less

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Brigham and Women's Hospital and Harvard Medical School, Boston, MA
OSTI Identifier:
6856326
Alternate Identifier(s):
OSTI ID: 6856326
Report Number(s):
CONF-850611-
Journal ID: CODEN: JNMEA; TRN: 87-010640
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; SCINTISCANNING; MYOCARDIAL INFARCTION; DIAGNOSIS; MYOCARDIUM; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; UPTAKE; IMAGES; INTRAVENOUS INJECTION; PATIENTS; RETENTION FUNCTIONS; TECHNETIUM 99; TECHNETIUM COMPLEXES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPLEXES; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; DRUGS; FUNCTIONS; HOURS LIVING RADIOISOTOPES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TRANSITION ELEMENT COMPLEXES; YEARS LIVING RADIOISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Holman, B.L., Campbell, S., Kirshenbaum, J.M., Lister-James, J., Jones, A.G., Davison, A., and Antman, E. Radionuclide imaging of myocardial infarction using Tc-99m TBI. United States: N. p., 1985. Web.
Holman, B.L., Campbell, S., Kirshenbaum, J.M., Lister-James, J., Jones, A.G., Davison, A., & Antman, E. Radionuclide imaging of myocardial infarction using Tc-99m TBI. United States.
Holman, B.L., Campbell, S., Kirshenbaum, J.M., Lister-James, J., Jones, A.G., Davison, A., and Antman, E. Wed . "Radionuclide imaging of myocardial infarction using Tc-99m TBI". United States.
@article{osti_6856326,
title = {Radionuclide imaging of myocardial infarction using Tc-99m TBI},
author = {Holman, B.L. and Campbell, S. and Kirshenbaum, J.M. and Lister-James, J. and Jones, A.G. and Davison, A. and Antman, E.},
abstractNote = {The cationic complex Tc-99m t-butylisonitrile (TBI) concentrates in the myocardial tissue of several animal species. Its myocardial distribution is proportional to blood flow both in zones of ischemia and in normal myocardium at rest. Planar, tomographic, and gated myocardial images have been obtained using Tc-99m TBI in the human. The authors investigated the potential application of Tc-99m TBI imaging to detect and localize myocardial infarction. Four subjects without clinical evidence of cardiovascular disease and five patients with ECG evidence of previous myocardial infarction were studied. Tc-99m TBI (10mCi) was injected intravenously with the patient in a resting state with planar imaging in the anterior, 30 and 70 degree LAO projections beginning one hr after injection. The distribution of the tracer was homogeneous throughout the left ventricular wall in the normal subjects. Regional perfusion defects were present in 4/5 of the patients with myocardial infarction. Location of the defects corresponded to the location of the infarct using ECG criteria (2 inferoposterior and 2 anterior). The patient in whom the Tc-99m TBI image appeared normal had sustained a subendocardial myocardial infarct which could not be localized by ECG; the other 4 pts had transmural infarcts. Anterior and 30 degree LAO images were of excellent quality in all cases; there was overlap of the liver on the inferior wall of the left ventricle on the 70 degree LAO views. The authors conclude that accurate perfusion imaging may be possible using Tc-99m TBI in patients with transmural myocardial infarction.},
doi = {},
journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 26:5,
place = {United States},
year = {1985},
month = {5}
}

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