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Standardization and imaging of arterial and venous thrombosis models in rabbits with Ga-67-fibrinogen-DAS-DFO, new bifunctional chelating agent

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6856016
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The purpose of the study is to make the standardization of arterial and venous thrombosis models in the rabbits and to obtain their images by Ga-67-fibrinogen-DAS-DFO, new bifunctional chelating agent preserving the high biological activity of fibrinogen. Arterial thrombus was induced by perivascular application of silver nitrate solution on the isolated femoral artery in rabbits, and venous thrombus by that of formalin on the femoral vein. Ga-67-fibrinogen-DAS-DFO or In-111 oxine platelet was injected 2 hours after thrombus formation, to get the images of fresh thrombus; Ga-67-fibrinogen-DAS-DFO was injected 1 day or 2 days after thrombus formation to get the images of old thrombus. Scinti-images of GA-67-fibrinogen-DAS-DFO showed the excessive accumulation in fresh arterial and venous thrombi, 6 hours after injection; the ratio of the radioactivity of arterial thrombus to blood was 6.92 +- 0.27 and that of venous thrombus to blood was 6.89 +- 0.61. They showed the increased accumulation in 1 day(old arterial and venous thrombi, too, but no significant accumulation in 2 day-old arterial and venous thrombi. Scinti-images of In-111 oxine platelet showed the excessive accumulation in fresh arterial and venous thrombi, 24 hours after injection. Ga-67-fibrinogen-DAS-DFO could detect arterial and venous-fresh and 1 day-old thrombus, 6 hours after injection, and obtain earlier images of thrombus than In-111 oxine platelet. Thrombus formation was recognized in all experiments.

Research Organization:
Shiga Medical School, Ohtsu
OSTI ID:
6856016
Report Number(s):
CONF-850611-
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHELATES
CHELATING AGENTS
CHEMICAL PREPARATION
CHEMISTRY
COAGULANTS
COMPLEXES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMBOLI
EVALUATION
FIBRINOGEN
GALLIUM 67
GALLIUM ISOTOPES
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
IMAGE PROCESSING
IMAGES
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
MATERIALS
MATHEMATICAL MODELS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROCESSING
PROTEINS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
STANDARDIZATION
SYNTHESIS
THROMBOSIS
USES
VASCULAR DISEASES
VEINS
VERTEBRATES