N-13 ammonia positron tomography at rest and during exercise for evaluation of coronary artery disease

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6855978

Tamaki, N; Yonekura, Y; Senda, M; Saji, H; Kodama, S; Konishi, Y; Ban, T; Kambara, H; Kawai, C; Torizuka, K

To assess the value of positron computed tomography (PCT) for evaluation of coronary artery disease (CAD), N-13 ammonia myocardial PCT was performed at rest and during exercise in 23 cases. PCT imaging was taken with a wholebody multislice PCT device 3 minutes after intravenous injection of 20-20 mCi of N-13 ammonia. The tracer distribution was homogenous in the left ventricular myocardium at rest and during exercise in all 4 normal cases. Among 19 cases with CAD, regional hypoperfusion was observed in 24 cases (74%) at rest and 18 cases (95%) during exercise. Furthermore, 12 cases had regional perfusion abnormalities in stress images not present at rest. Segmental analysis of myocardial perfusion identified 30 of the 34 stenosed vessels (88%) with only one false positive finding (specificity: 97%). In 11 patients who underwent both thallium-201 and N-13 ammonia imaging, PCT detected stenosed vessels more (87%) than the thallium-201 imaging (63%: p<0.05), especially in those with multivessel disease (87% vs 63%: p 0.05). For quantitative analysis of myocardial perfusion by PCT, % change in tracer concentration from resting to stress state was calculated. It was mildly increased (14.4+- 5.8%: p<0.001) in normal segments, whereas in CAD, it was significantly decreased (-18.0+- 18.3%: p<0.02) in segments with stenosed vessels. The authors conclude that N-13 ammonia PCT during exercise is a sensitive and effective method for detecting CAD and identifying stenosed vessels, and it permits quantitative assessment of coronary reserve function.

• Research Organization: Kyoto Univ. Medical School, Kyoto
• OSTI ID: 6855978
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMMONIA
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
BODY AREAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEST
COMPUTERIZED TOMOGRAPHY
CORONARIES
COUNTING TECHNIQUES
DETECTION
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVALUATION
EXERCISE
HEART
HYDRIDES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
LABELLING
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NITROGEN 13
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PERFORMANCE
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SEQUENTIAL SCANNING
TOMOGRAPHY
TRACER TECHNIQUES