No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Environ. Mol. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2850110206· OSTI ID:6855771

Cain, K T; Cornett, C V; Cacheiro, L A; Hughes, L A; Owens, J G; Generoso, W M

Calcium cyclamate, an artificial sweetener, was studied for its effectiveness in inducing transmissible chromosomal aberrations in germ cells of male mice. Both the dominant-lethal and the heritable translocation tests were carried out following daily treatment (on weekdays) of males by oral intubation with the maximum tolerated dose for 6 weeks. Calcium cyclamate is negative in both tests; therefore, there is no evidence of induced chromosome breakage and exchange.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6855771
• Journal Information: Environ. Mol. Mutagen.; (United States), Journal Name: Environ. Mol. Mutagen.; (United States) Vol. 11:2; ISSN ENMUE
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
CHROMOSOMAL ABERRATIONS
DOMINANT MUTATIONS
GENETIC EFFECTS
GERM CELLS
LETHAL MUTATIONS
MALES
MAMMALS
MICE
MUTATION FREQUENCY
MUTATIONS
ORGANIC COMPOUNDS
RODENTS
VERTEBRATES