Description and validation of a method for simultaneous estimation of effective population size and mutation rate from human population data
- Univ. of Texas Graduate School of Biomedical Sciences, Houston (USA)
- Univ. of Michigan Medical School, Ann Arbor (USA)
A method is presented for utilizing population data on electrophoretic variants of proteins to estimate simultaneously the effective sizes (N{sub e} values) of the populations in question and the rate of mutation resulting in electromorphs at the loci whose products were surveyed. The method is applied to data from 12 relatively unacculturated Amerindian tribes for whom census data and independent estimates of the number of different electrophoretic variants at 27 loci are available. Because of the tribal demographic structure, N{sub e} should be less than the current number of reproductive-aged adults. In fact, it is substantially greater for 7 tribes, most likely due to intertribal migration and a recent decrease in tribal size. Estimates of lucus mutation rates for the 27 loci vary by more than a factor of 20, with an average of 1.1 {times} 10{sup {minus}5} per locus per generation. This latter estimate is in satisfactory agreement with the results of other indirect approaches to the estimation of mutation rates in these tribes but about two times higher than the results of direct estimates based on these same loci in studies on civilized populations. This discrepancy could be due to the above-hypothesized migration and to decreases in tribal size.
- OSTI ID:
- 6855072
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:23; ISSN 0027-8424
- Country of Publication:
- United States
- Language:
- English
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