Value of quantitative exercise thallium-201 scintigraphy for predicting restenosis after successful percutaneous transluminal coronary angioplasty

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6854966

Stuckey, T D; Watson, D D; Nygaard, T W; Burwell, L R; Gibson, R S; Beller, G A

The authors sought to determine the ability of quantitative exercise thallium-201 (Tl-201) scintigraphy (ex-T1) to predict early restenosis following angiographically successful percutaneous transluminal coronary angioplasty (PTCA). Ex-Tl was performed 2.6 +- 2.1 weeks (range 0-9) weeks following PTCA in 55 patients; exercise was symptom limited in 54 and heart rate limited in 1. During a mean followup period of 8.5 months (range 3-24), restenosis occurred in 11 patients (20%) and myocardial infarction in 1 (1.7%); restenosis occurred 2.2 +- 1.1 months following the procedure. Of this group, only one patient (1/12; 8%) demonstrated unequivocal redistribution in the scan region of the dilated vessel; other patterns included two patients with delayed washout, three with persistent defects, and six with normal Tl-201 uptake and washout. Eight patients (8/55; 15%) demonstrated redistribution in the scan region of the dilated vessel following PTCA. Of these, five had angiographic evidence of incomplete revascularization with stenosis (greater than or equal to 50%) involving the distal dilated vessel or side branches. The authors conclude that: 1) Normalization of myocardial perfusion as assessed by ex-Tl following PTCA does not preclude early restenosis; and 2) Evidence of residual ischemia by ex-Tl in the scan region of the dilated vessel following PTCA is frequently associated with angiographic evidence of incomplete revascularization.

• Research Organization: Univ. of Virginia Medical Center, Charlottesville, VA
• OSTI ID: 6854966
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EXERCISE
HEART
HEAVY NUCLEI
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MONITORING
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RECOVERY
REPAIR
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SURGERY
THALLIUM 201
THALLIUM ISOTOPES
VASCULAR DISEASES