Bone-density-specific fracture risk: A population-based study of the relationship between osteoporosis and vertebral fractures
The search for a specific level of bone density that clearly distinguishes patients with osteoporosis from those without has been largely unsuccessful. A different, ''gradient of risk'' model was used to assess the effect of various degrees of osteoporosis on the prevalence of vertebral fractures. The authors measured spinal (L/sub 1/-L/sub 4/) bone mineral (BM) with dual photon absorptiometry in an age-stratified random sample of Rochester, Minnesota women greater than or equal to 35 years old to estimate the distribution of spinal BM in the population of adult woman. The authors also assessed BM among women in the sample who had one or more vertebral fractures to estimate both the total number of women with vertebral fractures in the population and the distribution of spinal BM in such women. These population-based estimates were then used to calculate the prevalence rate of vertebral fracture at various levels of spinal BM. Women with spinal BM greater than or equal to 1.40 g/cm/sup 2/ were free of vertebral fractures. Among women with BM between 1.00 and 1.39 g/cm/sup 2/, the prevalence of vertebral fractures was about 7%. The prevalence rate increased as spinal BM decreased further. Among women with spinal BM<0.60 g/cm/sup 2/, all had at least one vertebral fracture (prevalence=100%). These data indicate that osteoporosis is a necessary cause of age-related vertebral fractures and, at certain low levels, is a sufficient cause of such fractures in conjunction with the activities of daily living.
- Research Organization:
- Mayo Clinic, Rochester, MN
- OSTI ID:
- 6852417
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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BONE FRACTURES
CORRELATIONS
DETECTION
BONE TISSUES
OSTEODENSITOMETRY
OSTEOPOROSIS
QUANTITATIVE CHEMICAL ANALYSIS
RELIABILITY
DIAGNOSIS
VERTEBRAE
CHEMICAL COMPOSITION
DENSITY
MATHEMATICAL MODELS
MINERALS
ANIMAL TISSUES
BIOMEDICAL RADIOGRAPHY
BODY
CHEMICAL ANALYSIS
CONNECTIVE TISSUE
DIAGNOSTIC TECHNIQUES
DISEASES
INJURIES
MEDICINE
NUCLEAR MEDICINE
ORGANS
PHYSICAL PROPERTIES
RADIOLOGY
SKELETAL DISEASES
SKELETON
TISSUES
550900* - Pathology