Radiation-induced skin cancer and radiodermatitis of the head and neck

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19870201)59:3<411::AID-CNCR2820590310>3.0.CO;2-Z· OSTI ID:6850259

van Vloten, W A; Hermans, J; van Daal, W A

From a cohort of 2400 patients who had been irradiated 19 to 48 years previously for benign diseases in the head and neck region a randomly selected group of 605 patients was selected and traced back. From the 360 patients alive, 257 were examined clinically and 49 were examined by questionnaire for radiation-induced skin tumors and radiodermatitis. In 21 patients, a total of 30 skin tumors were diagnosed. In 8 of 21 patients, 10 skin carcinomas were detected at recall. A dose-effect relationship of 40 carcinomas/10(4) persons/Gy for a median follow-up period of 41 years for the area exposed was calculated. The severity of radiodermatitis is associated with a higher prevalence of skin cancer. The number of radiation-induced skin cancers rises with the post-treatment time. Because of these late radiation effects, radiotherapy of benign skin lesions is contraindicated, especially now that other therapy modalities are available.

• Research Organization: University Hospital, Utrecht, The Netherlands
• OSTI ID: 6850259
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 3; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

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560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
DELAYED RADIATION EFFECTS
DERMATITIS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HEAD
INJURIES
LOCAL RADIATION EFFECTS
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIODERMATITIS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKIN
SKIN DISEASES
THERAPY