Two-stage carcinogenesis studies with asbestos in Fisher 344 rats

Journal Article · Mon Sep 01 00:00:00 EDT 1980 · J. Natl. Cancer Inst.; (United States)

OSTI ID:6850157

Topping, D C; Nettesheim, P

The cocarcinogenic effect of chrysotile asbestos was investigated in heterotopic tracheal transplants of F344 rats. Tracheal transplants were first exposed to graded doses of dimethylbenz(a)anthracene (DMBA) contained in intraluminal pellets. Four weeks after the start of DMBA the spent pellets were removed, and 200 ..mu..g chrysotile, a nontumorigenic dose of asbestos, was introduced into the lumina of the preexposed tracheas. No significant enhancement of the tumor response was seen with 100 ..mu..g DMBA, a dose that was tumorigenic by itself. However, with 50 and 25 ..mu..g DMBA, nontumorigenic dose levels, a 15 and 23% incidence of tracheal carcinomas occurred when DMBA exposure was followed by a nontumorigenic dose of chrysotile. At 12.5..mu..g DMBA, this effect was not observed.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6850157
• Journal Information: J. Natl. Cancer Inst.; (United States), Vol. 65:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASBESTOS
CARCINOGENESIS
SYNERGISM
DIMETHYLBENZANTHRACENE
IMPLANTS
NEOPLASMS
RATS
TRACHEA
TRANSPLANTS
ANIMALS
AROMATICS
CONDENSED AROMATICS
DISEASES
MAMMALS
ORGANIC COMPOUNDS
PATHOGENESIS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)