Chromosomal location of the Syk and ZAP-70 tyrosine kinase genes in mice and humans
- Centre d`Immunologie INSERM-CNRS de Marseille-Luminy (France)
- Hopital des Enfants, Marseille (France)
Several protein tyrosine kinases (PTKs), which may be grouped into two structurally different families, have been implicated in antigen receptor proximal signaling. Blk, Fyn, Lck, Lyn, and Yes belong to the Src-family kinases, whereas the spleen tyrosine kinase (Syk) and the CD3-{zeta}-associated PTK (ZAP-70) define a new one, the Syk family. These kinases differ from the Src-family kinases in that they are non-myristylated cytoplasmic polypeptides composed of two N-terminal Src homology-2 (SH2) domains and a C-terminal catalytic domain. ZAP-70 appears to be expressed exclusively in T cells and NK cells, whereas Syk is preferentially expressed in B cells, T cells, and myeloid cells. 15 refs., 2 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 68498
- Journal Information:
- Immunogenetics, Journal Name: Immunogenetics Journal Issue: 4 Vol. 40; ISSN 0093-7711; ISSN IMNGBK
- Country of Publication:
- United States
- Language:
- English
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