Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Identification of donor-derived antigen-specific suppressor cells in murine bone marrow chimeras prepared with total-lymphoid irradiation

Journal Article · · Transplantation; (United States)
OSTI ID:6847457
; ;
The suppressor activity of the spleen cells from bone marrow chimeras prepared with total-lymphoid irradiation was analyzed in vitro. The chimeric spleen cells lacked responsiveness to host-type, but not to third-party, antigens in the mixed-leukocyte reaction (MLR) as judged by (3H)thymidine incorporation and the generation of cytolytic cells. When the donor-type chimeric spleen cells were used as cocultured cells in the MLR, modest nonspecific suppression of (3H)thymidine incorporation and potent antigen-specific suppression of the generation of the cytolytic cells was observed. The donor-type suppressor cells may play an important role in preventing graft-versus-host disease in vivo.
OSTI ID:
6847457
Journal Information:
Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 36:4; ISSN TRPLA
Country of Publication:
United States
Language:
English

Similar Records

Spleen cells from adult mice given total lymphoid irradiation or from newborn mice have similar regulatory effects in the mixed leukocyte reaction. I. Generation of antigen-specific suppressor cells in the mixed leukocyte reaction after the addition of spleen cells from adult mice given total lymphoid irradiation
Journal Article · Sun Aug 01 00:00:00 EDT 1982 · J. Exp. Med.; (United States) · OSTI ID:6942601
Nonspecific suppressor elements in murine allogeneic radiation chimeras
Journal Article · Sat Sep 15 00:00:00 EDT 1979 · Cell. Immunol.; (United States) · OSTI ID:5369825
Spleen cells from adult mice given total lymphoid irradiation (TLI) or from newborn mice have similar regulatory effects in the mixed leukocyte reaction (MLR). II. Generation of antigen-specific suppressor cells in the MLR after the addition of spleen cells from newborn mice
Journal Article · Sun Oct 31 23:00:00 EST 1982 · J. Immunol.; (United States) · OSTI ID:5683125

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CELL CULTURES
CHIMERAS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IMMUNOLOGY
IMMUNOSUPPRESSION
IRRADIATION
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGHT NUCLEI
LYMPHATIC SYSTEM
MAMMALS
MICE
MOSAICISM
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIATION CHIMERAS
RADIATION EFFECTS
RADIOIMMUNOLOGY
RADIOISOTOPES
REACTION KINETICS
RIBOSIDES
RODENTS
SOMATIC CELLS
SPLEEN
SPLEEN CELLS
THYMIDINE
TISSUES
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES