2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in the environment: human health risk estimation and its application to the Seveso case as an example

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · Regul. Toxicol. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0273-2300(86)90016-4· OSTI ID:6846662

di Domenico, A; Zapponi, G A

Findings from selected dose-response experimental studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) carcinogenic action in rodents were utilized for low-dose lifetime cancer risk estimation in man. The Weibull, Armitage-Doll, and linearized Armitage-Doll mathematical models were employed in this work. Conversion factors, based on body surface, of 1/5 and 1/11 were also employed for rat- and mouse-to-man extrapolation. Conservative estimates from the linearized Armitage-Doll upper 99% confidence limit associate a 10(-5) risk probability level to TCDD daily doses of 0.15-2.4 pg/kg body wt., while levels of 10(-6) and 10(-7) are associated with uptakes 10- and 100-fold lower, respectively. Based on environmental microanalytical records, exposure to TCDD of Seveso (Milan, Italy) Zone B and R inhabitants was calculated from 0.5 year after the accident onward. Exposure through food produced locally was assumed to be zero. The lifetime cancer risk for the considered cohort at the highest exposure does not appear to exceed 10(-5).

• Research Organization: Istituto Superiore di Sanita, Roma, Italy
• OSTI ID: 6846662
• Journal Information: Regul. Toxicol. Pharmacol.; (United States), Journal Name: Regul. Toxicol. Pharmacol.; (United States) Vol. 3; ISSN RTOPD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
DIOXIN
DISEASES
ENVIRONMENTAL EXPOSURE
EUROPE
EXTRAPOLATION
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC COMPOUNDS
ITALY
MAMMALS
MAN
MATHEMATICAL MODELS
MICE
NEOPLASMS
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PRIMATES
RATS
RISK ASSESSMENT
RODENTS
VERTEBRATES
WESTERN EUROPE