skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Usefulness of radionuclide angiocardiography in predicting stenotic mitral orifice area

Abstract

Fifteen patients with pure mitral stenosis (MS) underwent high-temporal-resolution radionuclide angiocardiography for calculation of the ratio of peak left ventricular (LV) filling rate divided by mean LV filling rate (filling ratio). Whereas LV filling normally occurs in 3 phases, in MS it is more uniform. Thus, in 13 patients the filling ratio was below the normal range of 2.21 to 2.88 (p less than 0.001). In 11 patients in atrial fibrillation, filling ratio divided by mean cardiac cycle length and by LV ejection fraction provided good correlation (r = 0.85) with modified Gorlin formula derived mitral area and excellent correlation with echocardiographic mitral area (r = 0.95). Significant MS can be detected using radionuclide angiocardiography to calculate filling ratio. In the absence of the confounding influence of atrial systole calculation of 0.14 (filling ratio divided by cardiac cycle length divided by LV ejection fraction) + 0.40 cm2 enables accurate prediction of mitral area (+/- 4%). Our data support the contention that the modified Gorlin formula, based on steady-state hemodynamics, provides less certain estimates of mitral area for patients with MS and atrial fibrillation, in whom echocardiography and radionuclide angiocardiography may be more accurate.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Toronto Western Hospital, Canada
OSTI Identifier:
6845267
Alternate Identifier(s):
OSTI ID: 6845267
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. J. Cardiol.; (United States); Journal Volume: 13
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; BIOMEDICAL RADIOGRAPHY; ACCURACY; BLOOD FLOW; CARDIOVASCULAR DISEASES; DIAGNOSIS; PATIENTS; TECHNETIUM 99; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics

Citation Formats

Burns, R.J., Armitage, D.L., Fountas, P.N., Tremblay, P.C., and Druck, M.N. Usefulness of radionuclide angiocardiography in predicting stenotic mitral orifice area. United States: N. p., 1986. Web. doi:10.1016/0002-9149(86)90385-1.
Burns, R.J., Armitage, D.L., Fountas, P.N., Tremblay, P.C., & Druck, M.N. Usefulness of radionuclide angiocardiography in predicting stenotic mitral orifice area. United States. doi:10.1016/0002-9149(86)90385-1.
Burns, R.J., Armitage, D.L., Fountas, P.N., Tremblay, P.C., and Druck, M.N. Mon . "Usefulness of radionuclide angiocardiography in predicting stenotic mitral orifice area". United States. doi:10.1016/0002-9149(86)90385-1.
@article{osti_6845267,
title = {Usefulness of radionuclide angiocardiography in predicting stenotic mitral orifice area},
author = {Burns, R.J. and Armitage, D.L. and Fountas, P.N. and Tremblay, P.C. and Druck, M.N.},
abstractNote = {Fifteen patients with pure mitral stenosis (MS) underwent high-temporal-resolution radionuclide angiocardiography for calculation of the ratio of peak left ventricular (LV) filling rate divided by mean LV filling rate (filling ratio). Whereas LV filling normally occurs in 3 phases, in MS it is more uniform. Thus, in 13 patients the filling ratio was below the normal range of 2.21 to 2.88 (p less than 0.001). In 11 patients in atrial fibrillation, filling ratio divided by mean cardiac cycle length and by LV ejection fraction provided good correlation (r = 0.85) with modified Gorlin formula derived mitral area and excellent correlation with echocardiographic mitral area (r = 0.95). Significant MS can be detected using radionuclide angiocardiography to calculate filling ratio. In the absence of the confounding influence of atrial systole calculation of 0.14 (filling ratio divided by cardiac cycle length divided by LV ejection fraction) + 0.40 cm2 enables accurate prediction of mitral area (+/- 4%). Our data support the contention that the modified Gorlin formula, based on steady-state hemodynamics, provides less certain estimates of mitral area for patients with MS and atrial fibrillation, in whom echocardiography and radionuclide angiocardiography may be more accurate.},
doi = {10.1016/0002-9149(86)90385-1},
journal = {Am. J. Cardiol.; (United States)},
number = ,
volume = 13,
place = {United States},
year = {Mon Dec 01 00:00:00 EST 1986},
month = {Mon Dec 01 00:00:00 EST 1986}
}