Use of diethyl-IDA Tc 99m clearance curves in the differentiation of biliary atresia from other forms of neonatal jaundice

Journal Article · Mon Mar 01 04:00:00 EST 1982 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.142.3.7063701· OSTI ID:6844076

Leonard, J C; Hitch, D C; Manion, C V

A family of isotope elimination curves that reflects changes in the biodistribution of diethyl-IDA Tc 99m in neonatal cholestatic jaundice and biliary atresia is defined. Time/activity curves generated from equal areas over the heart and liver were evaluated separately and in conjunction with the scintigraphic data. Patients without scintigraphic evidence of significant hepatic uptake and with hepatic curve that resembled the cardiac curve were found to have neonatal hepatitis. Good hepatic uptake and a hepatic curve with a terminal portion that appeared to be parallel to or divergent from the cardiac curve were associated with biliary atresia. Apparently converging hepatic and cardiac curves were associated with biliary patency. Although preliminary, these results provide further documentation that diethyl-IDA Tc 99m is useful in discriminating biliary atresia from other causes of cholestatic jaundic, while reducing radiation exposure and the need for pharmacologic intervention.

• Research Organization: Oklahoma Children's Memorial Hospital, Oklahoma City
• OSTI ID: 6844076
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 142:3; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
BODY
CARDIOVASCULAR SYSTEM
CHILDREN
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
DRUGS
DYNAMIC FUNCTION STUDIES
EXCRETION
GLANDS
HEART
HEPATITIS
HOURS LIVING RADIOISOTOPES
IMINES
INFANTS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
JAUNDICE
LABELLED COMPOUNDS
LIVER
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
YEARS LIVING RADIOISOTOPES