Infarct size after reperfusion by simultaneous intracoronary In-111-monoclonal antimyosin and Tc-99mPyrophosphate: Comparison by gamma scintigraphy
To determine if Tc-99m labeled pyrophosphate (PYP) and In-111 labeled antimyosin (AM) identify similar zones of acute myocardial infarction (MI), their distribution was determined in 7 dogs, and the results compared to a triphenyl tetrazolium chloride (TTC) measurement of the MI. Seven anesthetized open chest dogs had a 3 hr LAD occlusion. After 15 min of reperfusion, a mixture of 4mCi of Tc-99m PYP and 2mCi In-111 AM was administered into the LAD via the coronary artery catheter. The dogs were killed 45 min later; the hearts sliced into 0.5cm sections parallel to the atrioventricular groove and then stained with TTC. The 0.5 cm slices were imaged with a gamma camera equipped with a medium energy collimator at 140 KeV for Tc-99m and 260KeV for In-111. The Tc-99m and In-111 images of the slices were normalized to the pixel with highest intensity and the area of radioactivity planimetered. Ratios of pixel density of PYP to In-111 AM (P/A) were compared. In 6 dogs with small to moderate TTC infarcts (No. pixels SD=1131 +- 445), P/A=1.97 +- 0.36 (mean +- SD), whereas P/A=0.78 only in a dog with a large infarct (No. pixels=2159). TTC stained MIs were almost identical to AM delineated MIs but were smaller than PYP delineated areas of damage. These results indicated that in large infarcts, the AM delineated infarct is approximately equal to PYP infarct. But in small to medium size infarcts where a large zone of severely compromised but reversibly injured myocardium may exist, PYP delineated area of MI is approximately twice that shown by AM. Comparison of these 2 zones of myocardial compromise may provide important information for delineation of severely but reversibly effected myocardium.
- Research Organization:
- General Hospital, Boston, MA
- OSTI ID:
- 6843961
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
COLLIMATORS
CORONARIES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
ENERGY RANGE
GAMMA CAMERAS
HALIDES
HALOGEN COMPOUNDS
HEART
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
IMAGES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KEV RANGE
KEV RANGE 100-1000
LABELLING
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TETRAZOLES
TETRAZOLIUM
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES