SPECT quantification of myocardial mass with Thallium-201: Comparison of 180/sup 0/ vs 360/sup 0/ acquisitions
It has recently been proposed that, for the heart, tomographic acquisitions over 180/sup 0/ (30/sup 0/ RAO to 60/sup 0/ LPO) might yield more relevant reconstructions than for 360/sup 0/. The authors have compared the effect of both formats using an Iowa heart phantom placed in the appropriate orientation in an Alderson torso phantom. Chamber activity of 2 ..mu..Ci/cc was used to emulate myocardial T1-201 uptake whereas background activity in the chest phantom was varied from 0 to .3 ..mu..Ci/cc; the latter encompasses the measured target-to-background ratios obtained on stress and redistribution Tl-201 scintigrams of twelve patients. Transaxial reconstructions were made with and without attenuation compensation (AC) for both 180/sup 0/ (30/sup 0/ RAO to 60/sup 0/ LPO) and 360/sup 0/. After formatting into oblique data sets holding 19 slices perpendicular to the long axis of the heart phantom, an algorithm estimating volumes above a certain count threshold of maximum was used to estimate myocardial mass. Defects were introduced into the phantom and the tomographic acquisitions repeated. Attenuation compensated 180/sup 0/ acquisitions yielded appropriate estimates of myocardial mass, even when large defects were reoriented from the septal to the lateral wall. The authors conclude that Tl-201 SPECT derived estimates of myocardial mass can be made from 180/sup 0/ acquisitions if (1) attenuation compensation is used, (2) corrections are made for different background activities in the ''lungs''.
- Research Organization:
- Women's Hospital and Harvard Medical School, Boston, MA
- OSTI ID:
- 6843425
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ALGORITHMS
ATTENUATION
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CHEST
COMPUTERIZED TOMOGRAPHY
CORRECTIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MATHEMATICAL LOGIC
MOCKUP
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHANTOMS
RADIOISOTOPES
RESPIRATORY SYSTEM
SECONDS LIVING RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STRUCTURAL MODELS
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
UPTAKE