Quantitative analysis of thallium-201 myocardial emission computed tomography

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6843358

Okada, M; Kawai, N; Yamamoto, S; Matsushima, H; Kato, R; Tanahashi, Y; Sotobata, I; Obata, Y; Sakuma, S

The clinical usefulness of quantitative analysis of exercise thallium-201 myocardial emission computed tomography (ECT) was evaluated in twenty coronary artery disease patients and 10 normal controls. Longaxial and shortaxial myocardial images of left ventricle were interpreted quantitatively using circumferential profile analysis and two types of abnormality were studied: (1) diminished initial distribution (stress defect) and (2) slow washout of thallium-201, evidenced by patients' initial thallium-201 uptake and 3-hour washout rate profiles falling below the normal limits, respectively. Two diagnostic criteria, stress defect criterion and combined one of stress defect and slow washout, were used to detect significant coronary artery lesions (greater than or equal to75% luminal narrowing). The ischemic volume was also evaluated with quantitative analysis of thallium-201 ECT. The diagnostic accuracy of stress defect criterion was 95% in left ascending, 90% in right coronary and 78% in left circumflex coronary artery lesions. The combined criterion of stress defect and low washout increased detection sensitivity with moderate loss of specificity for identification of individual coronary artery lesions. The ischemic myocardial volume evaluated with combined criterion was significantly larger in triple vessel than in single vessel disease (p<0.05). It was concluded that quantitative analysis of exercise thallium-201 myocardial ECT images was useful for evaluation of coronary artery lesions.

• Research Organization: 1st Dept. of Internal Medicine and Dept. of Radiology, Nagoya Univ. School of Medicine, Nagoya
• OSTI ID: 6843358
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL STRESS
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
CORONARIES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EXERCISE
HEART
HEAVY NUCLEI
IMAGE PROCESSING
IMAGES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROCESSING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
USES