The effect of clomiphene on disuse bone loss
Clomiphene is a synthetic estrogen agonist/antagonist used for many years to induce ovulation in anovulatory women. A recent study demonstrated that clomiphene had a protective effect against bone loss in ovariectomized aged rats. The purpose was to determine if this drug retards resorption of bone associated with disuse in rats with intact ovaries. Eleven adult (300-350g) female rats received a pedicle bone graft (disuse) in one femur with the opposite limb serving as control. Of these, 6 received weekly 10 mg injections of clomiphone (Rx). Three Rx and three untreated (unRx) were sacrificed at 6 weeks while the remainder (3 Rx, 2 unRx) were sacrificed at 10 weeks after surgery. All received quantitative injections of MDP 24 hrs. before sacrifice and labeled microspheres (5) just prior to sacrifice. The % uptakes of MDP and S, total bone mineral (BMC) and regional BMC (RBMC) were determined. Results are expressed as a ratio of the pedicle bone to the bone from the opposite limb. At 6 weeks, MDP and S are elevated in both groups indicating that metabolic activity is elevated. The Rx group shows no change in BMC while the unRx lost 13%. At 10 weeks, MDP and S are close to one in both groups. The Rx group lost 13% BMC while the unRx lost 29%. The RBMC indicates that the early loss of mineral is located primarily in the metaphysis, a region rich in trabecular bone. These results indicate that clomiphene retards resorption of bone resulting from disuse.
- Research Organization:
- Space Center and Baylor College of Medicine, Houston, TX
- OSTI ID:
- 6842287
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
Similar Records
Intermittent treatment with human parathyroid hormone (hPTH[1-34]) increased trabecular bone volume but not connectivity in osteopenic rats
Extra cancellous bone induced by combined prostaglandin E2 and risedronate administration is maintained after their withdrawal in older female rats
Related Subjects
ESTROGENS
BIOLOGICAL EFFECTS
SKELETAL DISEASES
THERAPY
ABSORPTION
METABOLIC ACTIVATION
OVARIES
RATS
SKELETON
SURGERY
WOMEN
ANIMALS
BODY
DISEASES
FEMALE GENITALS
FEMALES
GONADS
HORMONES
MAMMALS
MAN
MEDICINE
ORGANS
PRIMATES
RODENTS
STEROID HORMONES
VERTEBRATES
550900* - Pathology