Chronic altitude plus carbon monoxide exposure causes left ventricular hypertrophy but an attenuation of coronary capillarity
To determine the nature of the cardiomegaly and coronary capillarity changes that occur with chronic hypoxia plus carbon monoxide (CO) exposure, F-344 rats (64-69 days old) were exposed to simulated altitude (18,000 ft) and four doses of CO (0, 50, 100, and 500 ppm) for six weeks. Left (LVT) and right (RVT) ventricular thickness and total coronary capillary density (LV Caps) were measured from sections of KCl-arrested hearts. Heart weight: Body weight ratios (HW:BW) were also calculated. Thus, altitude alone caused RV hypertrophy and an increase in LV Caps. Altitude plus CO attenuated the capillarity increase and caused further thickening of the LV but not the RV, suggesting concentric LV hypertrophy due to CO.
- Research Organization:
- Texas Tech Univ. School of Medicine, Lubbock
- OSTI ID:
- 6839954
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANOXIA
BIOLOGICAL EFFECTS
CARBON MONOXIDE
CORONARIES
HYPERTROPHY
ALTITUDE
CHRONIC EXPOSURE
RATS
SYNERGISM
WEIGHT
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARBON COMPOUNDS
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
MAMMALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology