Exposure to time varying magnetic fields associated with magnetic resonance imaging reduces fentanyl-induced analgesia in mice

Journal Article · Thu Dec 31 23:00:00 EST 1987 · Bioelectromagnetics (N.Y.); (United States)

DOI:https://doi.org/10.1002/bem.2250090208· OSTI ID:6839923

Teskey, G C; Prato, F S; Ossenkopp, K P; Kavaliers, M

The effects of exposure to clinical magnetic resonance imaging (MRI) on analgesia induced by the mu opiate agonist, fentanyl, was examined in mice. During the dark period, adult male mice were exposed for 23.2 min to the time-varying (0.6 T/sec) magnetic field (TVMF) component of the MRI procedure. Following this exposure, the analgesic potency of fentanyl citrate (0.1 mg/kg) was determined at 5, 10, 15, and 30 min post-injection, using a thermal test stimulus (hot-plate 50 degrees C). Exposure to the magnetic-field gradients attenuated the fentanyl-induced analgesia in a manner comparable to that previously observed with morphine. These results indicate that the time-varying magnetic fields associated with MRI have significant inhibitory effects on the analgesic effects of specific mu-opiate-directed ligands.

• Research Organization: St. Joseph's Health Center, London, Ontario (Canada)
• OSTI ID: 6839923
• Journal Information: Bioelectromagnetics (N.Y.); (United States), Journal Name: Bioelectromagnetics (N.Y.); (United States) Vol. 9:2; ISSN BLCTD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
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ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
CARBOXYLIC ACID SALTS
CITRATES
DIAGNOSTIC TECHNIQUES
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ELECTROMAGNETIC FIELDS
ENDORPHINS
INHIBITION
LIGANDS
MAMMALS
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NERVOUS SYSTEM DISEASES
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NMR IMAGING
RODENTS
VERTEBRATES